Concacaf has announced the field for round one of the 2025 Champions Cup, the highest level club competition in the confederation. Concacaf divides the field between 22 round one participants and a further 5 clubs that start in the round of 16. Round one is a home-and-away knockout round. The opening games of those series happen across February 4-6 and February 18-20. The Second legs are scheduled for February 11-13 and February 25-27.
Here are the round one clubs:
| CLUB | WON | PLAYS |
| Vancouver Whitecaps | 2024 Canadian Championship | Saprissa |
| Calvary FC | 2024 Canadian Premier League | UNAM Pumas |
| Forge FC | 2024 CPL Shield | CF Monterrey |
| Cibao | 2024 Caribbean Cup finalist | Chivas |
| Real Hope | 2024 Caribbean Cup 3rd-place | Cruz Azul |
| Real Esteli | 2024 Central American Cup | Tigres |
| Antigua | 2024 Central American Cup semifinalist | Seattle Sounders |
| Herediano | 2024 Central American Cup semifinalist | Real Salt Lake |
| Saprissa | 2024 Central American Cup play-in | Vancouver |
| Motagua | 2024 Central American Cup play-in | FC Cincinnati |
| LAFC | 2024 Leagues Cup runners-up | Colorado Rapids |
| Colorado Rapids | 2024 Leagues Cup 3rd-place | LAFC |
| Cruz Azul | 2023-24 Clausura runners-up | Real Hope |
| Tigres | 2023-24 Apertura runners-up | Real Esteli |
| CF Monterrey | 2023-24 Liga MX table | Forge FC |
| Chivas | 2023-24 Liga MX table | Cibao |
| UNAM Pumas | 2023-24 Liga MX table | Calvary |
| Inter Miami | 2024 MLS Supporters’ Shield | Sporting Kansas City |
| FC Cincinnati | Supporters’ Shield table | Motagua |
| Real Salt Lake | Supporters’ Shield table | Herediano |
| Seattle Sounders | Supporters’ Shield table | Antigua |
| Sporting Kansas City | 2024 US Open Cup runners-up | Inter Miami |
And here are the clubs already in the round of 16, with those games set for March 4-6 and March 11-13:
| CLUB | WON | WILL PLAY |
| Cavalier | 2024 Caribbean Cup | winner of Inter Miami vs Sporting KC |
| Alajuelense | 2024 Central American Cup | winner of UNAM Pumas vs Cavalry |
| Columbus Crew | 2024 Leagues Cup | winner of LAFC vs Colorado |
| Club America | 2023-24 Liga MX | winner of Chivas vs Cibao |
| LA Galaxy | 2024 MLS Cup | winner of Real Salt Lake vs Herediano |
The winners advance to the quarterfinals set for April 22-24 and April 29-May 1. The final will be on June 1 with the winner advancing to the 2025 FIFA Intercontinental Cup and the 2029 FIFA Club World Cup.
